Leukemia is cancer of white blood cells known to take the lives of 24,000 patients every year in the United States. There are many different types of leukemia, reflecting the diversity of the different types of white cells found in the human body and the different ages at which leukemia can develop. The most common […]
No human diseases have been cured without the assistance of animal research. Mouse models in particular have advanced pre-clinical studies and improved the outcome of a variety of serious medical conditions. Liver cancer is one malignancy with a high mortality rate, but animal research has enhanced the health outcomes of patients with this disease. One […]
Understanding the TCL1 oncogene has provided valuable insights for gaining a better understanding of the causal relationship between leukemia and T-cell defects of the immune system. Altered pathways and malignant transformations activated by mutation within the TCL1 oncogene in patients are accurately represented by the TCL1 transgenic mouse model. This animal model has been widely validated […]
Many early steps in cancer research began in either animal or tumor models. Without these prototypes, researchers would not have been able to create effective drug treatments or find a cure. In the 1960s, the earliest in vivo tumor models were developed, which were ascites models or murine leukemia models. A paper published in the […]
Murine models have served as a mainstay for preclinical cancer research trials for many decades, and continue to provide important insight into factors that influence malignant transformation of a tumor, tumor rate of growth, metastatic disease, and other activities. Two of the most widely used models include the mouse xenograft model and the genetically engineered […]
Today, patients who are diagnosed with cancer have a much higher likelihood of survival than in decades past. Fifty or sixty years ago, cancer was nearly always assigned a death sentence. Scientific cancer research, however, has brought effective treatments and increased the lifespan of most cancer patients. The advances that we have seen would not […]
The design of pre-clinical studies is a complex task, and understanding the translation from animal model to human diseases requires a great deal of care and a high level of understanding of both the basic science and the clinical condition. Many drugs in clinical development flounder due to lack of efficacy or unacceptable side effects. […]