Breast cancer is a difficult diagnosis to receive for any woman, as this disease leads to approximately 40,000 deaths in the United States every year. Breast cancer also affects about one in eight women throughout a lifetime. The healthcare sector and cancer drug market has focused on developing better treatments over the years, which has […]
Leukemia is cancer of white blood cells known to take the lives of 24,000 patients every year in the United States. There are many different types of leukemia, reflecting the diversity of the different types of white cells found in the human body and the different ages at which leukemia can develop. The most common […]
Advanced methods of combinatory chemistry have made it possible to quickly synthesize vast quantities of compounds for testing. These compounds are then tested in a rapid method of evaluation called high-throughput screening. High-throughput screening (HTS) allows researchers to quickly and cost-effectively process thousands and even hundreds of thousands (ultra-high-throughput screening, or uHTS) of compounds, which […]
Antibodies (Ab), or immunoglobulins (Ig), are naturally occurring proteins found in great abundance in our bodies. They are used by the immune system to identify and subdue antigens, or foreign substances that are found in the body which may cause disease or infection. Antibody engineering is a powerful resource for creating novel biopharmaceuticals. The most […]
No human diseases have been cured without the assistance of animal research. Mouse models in particular have advanced pre-clinical studies and improved the outcome of a variety of serious medical conditions. Liver cancer is one malignancy with a high mortality rate, but animal research has enhanced the health outcomes of patients with this disease. One […]
The development process of new therapeutics is one of several factors that directly impact the cost of healthcare today. Due to the amount of time and money involved, great efforts are being made to change the way drug candidates are processed, evaluated and selected. While certain processes were once approached as the next step of […]
Over twenty years ago, the agouti mouse was the first model cloned from which an obesity gene was described. Mutations in the agouti gene are associated with variations in coat color (stripes in cats and tigers), when an animal carries a single copy (or allele) of the gene. When the animal is homozygois for the […]
Until recently, the clinical research sector has had difficulty adopting computer modeling and simulation due to a variety of factors. Among these have been, the uncertain regulatory challenges of modeling and simulation applications, a lack of large-population data, and complicated biological systems. These factors have all prevented the utiliziation of computer modeling. However, these barriers […]
Inflammatory bowel diseases (IBD) are autoimmune conditions in which the immune system attacks regions of the digestive system. Crohn’s disease (CD) and ulcerative colitis (UC) are the two most common forms of IBD, differing in nature and location of inflammation within the digestive system. Although there are notable differences between CD and UC – which […]
The goal of lead optimization within the discovery phase of drug development is a multifaceted process, drawing from various compound properties to hone in on analogs that demonstrate the strongest potential for targeted therapies. Drug metabolism and pharmacokinetic (DMPK) property assessment is crucial to achieving desired biological activities and for determining safety profiles. DMPK data […]