Researchers have now developed an antibody therapy to treat Type 1 diabetes through the use of mouse models. A human clinical trial is now underway to see if the therapy rituximab is just as effective in people, according to the American Association for the Advancement of Science. Type 1 diabetes is a serious disorder that […]
Advanced methods of combinatory chemistry have made it possible to quickly synthesize vast quantities of compounds for testing. These compounds are then tested in a rapid method of evaluation called high-throughput screening. High-throughput screening (HTS) allows researchers to quickly and cost-effectively process thousands and even hundreds of thousands (ultra-high-throughput screening, or uHTS) of compounds, which […]
The development process of new therapeutics is one of several factors that directly impact the cost of healthcare today. Due to the amount of time and money involved, great efforts are being made to change the way drug candidates are processed, evaluated and selected. While certain processes were once approached as the next step of […]
Until recently, the clinical research sector has had difficulty adopting computer modeling and simulation due to a variety of factors. Among these have been, the uncertain regulatory challenges of modeling and simulation applications, a lack of large-population data, and complicated biological systems. These factors have all prevented the utiliziation of computer modeling. However, these barriers […]
The goal of lead optimization within the discovery phase of drug development is a multifaceted process, drawing from various compound properties to hone in on analogs that demonstrate the strongest potential for targeted therapies. Drug metabolism and pharmacokinetic (DMPK) property assessment is crucial to achieving desired biological activities and for determining safety profiles. DMPK data […]
Pharmacology — which is the study of the biomechanical or physiological effects of medicines and drugs on a cell, tissue, organ, or an organism — impacts the design of clinical studies significantly. Preclinical development and the planning stages in particular have a strong emphasis on pharmacology. In 1970, the first World Health Organization report on […]
If your pharmaceutical company is having difficulty managing the resources necessary to conduct pre-clinical studies, it could be in your best interest to outsource services to a contract research organization (CRO). When it comes to the drug development industry, the growth of CROs is accelerating, according to The Scientist publication. The first CROs appeared in […]
There are instances in drug development where modifications are made to a drug’s composition, formulation, equipment used, or manufacturing processes. These modifications require reassessment of the modified product to ensure the same pharmacological behavior. When a strong in-vitro-in-vivo correlation (IVIVC) is made, it effectively serves as a surrogate to costly in vivo bioequivalence studies, for […]