pharmacokinetic Archives

Jul, 2014

Sufficient Early ADME Profiling to Minimize Wasted Time and Expenditures

Posted on July 10, 2014 by Pharma Models Blogging Team in Toxicology and Pharmacology

The development process of new therapeutics is one of several factors that directly impact the cost of healthcare today. Due to the amount of time and money involved, great efforts are being made to change the way drug candidates are processed, evaluated and selected. While certain processes were once approached as the next step of […]

Jun, 2014

Harnessing the In-Vitro-In-Vivo Correlation in Drug Development

Posted on June 05, 2014 by Pharma Models Blogging Team in Toxicology and Pharmacology

There are instances in drug development where modifications are made to a drug’s composition, formulation, equipment used, or manufacturing processes. These modifications require reassessment of the modified product to ensure the same pharmacological behavior. When a strong in-vitro-in-vivo correlation (IVIVC) is made, it effectively serves as a surrogate to costly in vivo bioequivalence studies, for […]

Sufficient Early ADME Profiling to Minimize Wasted Time and Expenditures

Sufficient Early ADME Profiling to Minimize Wasted Time and Expenditures

Harnessing the In-Vitro-In-Vivo Correlation in Drug Development

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