Toxicology Testing of Biologics in Pre-Clinical Studies

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07
Jan, 2015

Toxicology Testing of Biologics in Pre-Clinical Studies

  • Posted on January 07, 2015 by Pharma Models Blogging Team in Immunology

Immunomodulatory biologics (“biologics”) are large molecules – proteins, peptides, and nucleotides – produced through biological processes in living cells and organisms. Currently, biologics represent one-third of newly licensed pharmaceutical products and target a broad range of diseases, mainly in oncology and autoimmune/inflammatory disorders. These biologics are generated through recombinant DNA-based techniques and are divided into […]

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30
Jun, 2014

The Role of Drug Metabolism and Pharmacokinetics in Lead Discovery and Optimization

The goal of lead optimization within the discovery phase of drug development is a multifaceted process, drawing from various compound properties to hone in on analogs that demonstrate the strongest potential for targeted therapies. Drug metabolism and pharmacokinetic (DMPK) property assessment is crucial to achieving desired biological activities and for determining safety profiles. DMPK data […]

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26
Jun, 2014

Pharmacology Research is Heating up This Summer

Pharmacology — which is the study of the biomechanical or physiological effects of medicines and drugs on a cell, tissue, organ, or an organism — impacts the design of clinical studies significantly. Preclinical development and the planning stages in particular have a strong emphasis on pharmacology. In 1970, the first World Health Organization report on […]

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09
Jun, 2014

How a Contract Research Organization can Help your Pre-clinical Studies

If your pharmaceutical company is having difficulty managing the resources necessary to conduct pre-clinical studies, it could be in your best interest to outsource services to a contract research organization (CRO). When it comes to the drug development industry, the growth of CROs is accelerating, according to The Scientist publication. The first CROs appeared in […]

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12
May, 2014

Welcome to the New Pharma Models Blog

The design of pre-clinical studies is a complex task, and understanding the translation from animal model to human diseases requires a great deal of care and a high level of understanding of both the basic science and the clinical condition. Many drugs in clinical development flounder due to lack of efficacy or unacceptable side effects. […]

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