The Role of Drug Metabolism and Pharmacokinetics in Lead Discovery and Optimization

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30
Jun, 2014

The Role of Drug Metabolism and Pharmacokinetics in Lead Discovery and Optimization

The goal of lead optimization within the discovery phase of drug development is a multifaceted process, drawing from various compound properties to hone in on analogs that demonstrate the strongest potential for targeted therapies. Drug metabolism and pharmacokinetic (DMPK) property assessment is crucial to achieving desired biological activities and for determining safety profiles. DMPK data […]

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28
May, 2014

The Importance of Toxicology Research in Preclinical Studies

Before a study reaches Phase I clinical trials, scientists spend years conducting preclinical research. One vital part of this includes performing toxicology research on a particular medication or pharmaceutical product. The U.S. Food and Drug Administration (FDA) put great emphasis on the importance of preclinical safety evaluations. According to the FDA’s guidance for industry on preclinical […]

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