TCL1 Transgenic Mice and T-Cell Dysfunction in Chronic Lymphocytic Leukemia

Understanding the TCL1 oncogene has provided valuable insights for gaining a better understanding of the causal relationship between leukemia and T-cell defects of the immune system. Altered pathways and malignant transformations activated by mutation within the TCL1 oncogene in patients are accurately represented by the TCL1 transgenic mouse model. This animal model has been widely validated […]