Tumor Xenografting in Mouse Models: A Necessity for Cancer Drug Development

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23
Oct, 2014

Tumor Xenografting in Mouse Models: A Necessity for Cancer Drug Development

  • Posted on October 23, 2014 by Pharma Models Blogging Team in Oncology

Pre-clinical cancer research – specifically drug development – often uses a standard procedure called tumor xenografting. This method essentially injects human cancer cell lines into mice to learn more about the mechanisms behind tumor growth and for developing effective cancer drugs, a paper published in Nature magazine explained. Subcutaneous xenografts, however, may have some limitations, as they are unable […]

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05
Aug, 2014

Chronic Myeloid Leukemia: A Cancer Not Meant for Children

  • Posted on August 05, 2014 by Pharma Models Blogging Team in Oncology

Chronic Myeloid Leukemia (CML) is a cancer of the white blood cells that forms in the bone marrow and travels through the cardiovascular system. With this particular type of leukemia, it takes much longer to develop symptoms. In fact, it may be a few years before symptoms are showing, according to The American Cancer Society. […]

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28
Jul, 2014

The Breast Cancer Drug Market Shoots for the Stars

  • Posted on July 28, 2014 by Pharma Models Blogging Team in Oncology

Breast cancer is a difficult diagnosis to receive for any woman, as this disease leads to approximately 40,000 deaths in the United States every year. Breast cancer also affects about one in eight women throughout a lifetime. The healthcare sector and cancer drug market has focused on developing better treatments over the years, which has […]

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26
Jun, 2014

Pharmacology Research is Heating up This Summer

Pharmacology — which is the study of the biomechanical or physiological effects of medicines and drugs on a cell, tissue, organ, or an organism — impacts the design of clinical studies significantly. Preclinical development and the planning stages in particular have a strong emphasis on pharmacology. In 1970, the first World Health Organization report on […]

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26
May, 2014

Four Tumor Models Vital in Our Search for a Cancer Cure

  • Posted on May 26, 2014 by Pharma Models Blogging Team in Oncology

Many early steps in cancer research began in either animal or tumor models. Without these prototypes, researchers would not have been able to create effective drug treatments or find a cure. In the 1960s, the earliest in vivo tumor models were developed, which were ascites models or murine leukemia models. A paper published in the […]

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21
May, 2014

Comparing Mouse Xenograft Models and Genetically Engineered Models

  • Posted on May 21, 2014 by Pharma Models Blogging Team in Oncology

Murine models have served as a mainstay for preclinical cancer research trials for many decades, and continue to provide important insight into factors that influence malignant transformation of a tumor, tumor rate of growth, metastatic disease, and other activities. Two of the most widely used models include the mouse xenograft model and the genetically engineered […]

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